Principal Investigators
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| Name: |
Guilherme Oliveira |
| Institution: |
FIOCRUZ - Institute Rene Rachou | Belo Horizonte | Brazil |
| E-mail: |
oliveira@cpqrr.fiocruz.br |
| Web: |
bioinfo.cebio.org/ |
| Brief: |
Our main interests are in S. mansoni genomics and the use of genomics data, using computational approaches, to identify drug targets and vaccine candidates. |
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| Name: |
Sérgio Verjovski-Almeida |
| Institution: |
Universidade de São Paulo | São Paulo | Brazil |
| E-mail: |
verjo@iq.usp.br |
| Web: |
www2.iq.usp.br/docente/verjo/ |
| Brief: |
Our laboratory focus is the epigenetic regulation of gene transcription exploring Gene Expression Signatures (GES) by microarrays, aiming at elucidating molecular pathways of S. mansoni that are affected by parasite treatment with HDAC inhibitors and at identifying acetylation posttranslational modifications in parasite histones. |
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| Name: |
Marcelo Fantappié |
| Institution: |
Universidade Federal do Rio de Janeiro | Rio de Janeiro | Brazil |
| E-mail: |
fantappie@bioqmed.ufrj.br |
| Web: |
- |
| Brief: |
Our main research is focused on the molecular mechanisms involved in gene regulation in S. mansoni. We have been interested in the roles that nuclear receptors and coactivators play, through chromatin remodeling, in the regulation of target genes of the parasite. |
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| Name: |
Dr. Christophe Romier |
| Institution: |
IGBMC | 1, rue Laurent Fries - B.P. 10142 - 67404 Illkirch Cedex | France |
| E-mail: |
romier@igbmc.fr |
| Web: |
www-bio3d-igbmc.u-strasbg.fr/~romier/ |
| Brief: |
Our main interest is the crystallographic study of epigenetic targets and the characterization of their structure-function relationships. In particular, we focus on the histone deacetylases from Schistosoma mansoni. |
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| Name: |
Wolfgang Sippl |
| Institution: |
Martin-Luther-University - Halle-Wittenberg | Halle | Germany |
| E-mail: |
wolfgang.sippl@pharmazie.uni-halle.de |
| Web: |
pc.pharmazie.uni-halle.de/medchem |
| Brief: |
Wolfgang Sippl is Professor for Medicinal Chemistry and Head of the Department of Pharmaceutical Chemistry at the Martin-Luther-University of Halle-Wittenberg (Germany). His main interests are computational chemistry and structure-based drug design with a focus on epigenetic targets. |
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| Name: |
Delphine Smagghe |
| Institution: |
Inserm-Transfert | Paris | France |
| E-mail: |
Karine.BAUDIN@inserm-transfert.fr |
| Web: |
www.inserm-transfert.fr/index.php |
| Brief: |
Inserm-Transfert is responsible for the coordination of the overall Intellectual Property and Tech Transfer activities of the SEtTReND consortium in collaboration with all the other beneficiaries. |
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| Name: |
Johan Schultz |
| Institution: |
iNovacia | Stockholm | Sweeden |
| E-mail: |
johan.schultz@inovacia.se |
| Web: |
www.inovacia.se/ |
| Brief: |
Our laboratory explores different aspects of the biology of reversible protein acetylation, a posttranslational modification that is gaining increasing recognition as an important biological regulatory mechanism. Our laboratory is focused on the enzymes that remove acetyl groups from proteins, the histone/protein deacetylases (HDACs). |
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